In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases

نویسندگان

  • Edward R. T. Tiekink
  • Peter D. Cookson
  • Bernadette M. Linahan
  • Lorraine K. Webster
چکیده

A series of phosphinegold(I) thionucleobase analogues, [R(3)PAu(SR(x))] (R = Et, Ph or chexyl; HSR(1) = 2-mercaptobenzoic acid, HSR(2) = 2-thiouracil, HSR(3) = 6-mercaptopurine and HSR(4) = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID(50) values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 muM. The complexes with SR(3) and SR(3) are generally the most active; however, there is no clear trend associated with the phosphine ligands.

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عنوان ژورنال:
  • Metal-Based Drugs

دوره 1  شماره 

صفحات  -

تاریخ انتشار 1994